Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer

Christopher Fang-Yen; Mark C. Chu; H. Sebastian Seung; Ramachandra R. Dasari; Michael S. Feld

doi:10.1364/OL.29.002028

Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer

Christopher Fang-Yen, Mark C. Chu, H. Sebastian Seung, Ramachandra R. Dasari, Michael S. Feld

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

We have used a novel phase-referenced heterodyne dual-beam low-coherence interferometer to perform what we believe are the first noncontact measurements of surface motion in a nerve bundle during the action potential. Nerve displacements of ∼5-nm amplitude and ∼10-ms duration are measured without signal averaging. This interferometer may find general application in measurement of small motion in cells and other weakly scattering samples.

Original language	English (US)
Pages (from-to)	2028-2030
Number of pages	3
Journal	Optics Letters
Volume	29
Issue number	17
DOIs	https://doi.org/10.1364/OL.29.002028
State	Published - Sep 1 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Atomic and Molecular Physics, and Optics

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10.1364/OL.29.002028

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abstract = "We have used a novel phase-referenced heterodyne dual-beam low-coherence interferometer to perform what we believe are the first noncontact measurements of surface motion in a nerve bundle during the action potential. Nerve displacements of ∼5-nm amplitude and ∼10-ms duration are measured without signal averaging. This interferometer may find general application in measurement of small motion in cells and other weakly scattering samples.",

author = "Christopher Fang-Yen and Chu, {Mark C.} and Seung, {H. Sebastian} and Dasari, {Ramachandra R.} and Feld, {Michael S.}",

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AU - Fang-Yen, Christopher

AU - Chu, Mark C.

AU - Seung, H. Sebastian

AU - Dasari, Ramachandra R.

AU - Feld, Michael S.

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N2 - We have used a novel phase-referenced heterodyne dual-beam low-coherence interferometer to perform what we believe are the first noncontact measurements of surface motion in a nerve bundle during the action potential. Nerve displacements of ∼5-nm amplitude and ∼10-ms duration are measured without signal averaging. This interferometer may find general application in measurement of small motion in cells and other weakly scattering samples.

AB - We have used a novel phase-referenced heterodyne dual-beam low-coherence interferometer to perform what we believe are the first noncontact measurements of surface motion in a nerve bundle during the action potential. Nerve displacements of ∼5-nm amplitude and ∼10-ms duration are measured without signal averaging. This interferometer may find general application in measurement of small motion in cells and other weakly scattering samples.

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JO - Optics Letters

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IS - 17

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Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer

Abstract

All Science Journal Classification (ASJC) codes

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