Nine-step enantioselective total synthesis of (+)-minfiensine

Spencer B. Jones, Bryon Simmons, David W.C. MacMillan

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311 Scopus citations


(Chemical Equation Presented) An enantioselective total synthesis of the Strychnos alkaloid (+)-minfiensine has been accomplished. Prominent features of this synthesis include (i) a new enantioselective organocatalytic Diels-Alder/amine cyclization sequence to build the central tetracyclic pyrroloindoline framework in four steps from commercial materials and (ii) a 6-exo-dig radical cyclization to forge the final piperidinyl ring system. This total synthesis of (+)-minfiensine was completed in nine chemical steps and 21% overall yield.

Original languageEnglish (US)
Pages (from-to)13606-13607
Number of pages2
JournalJournal of the American Chemical Society
Issue number38
StatePublished - 2009

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Biochemistry
  • Catalysis
  • Colloid and Surface Chemistry


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