Abstract
(Chemical Equation Presented) An enantioselective total synthesis of the Strychnos alkaloid (+)-minfiensine has been accomplished. Prominent features of this synthesis include (i) a new enantioselective organocatalytic Diels-Alder/amine cyclization sequence to build the central tetracyclic pyrroloindoline framework in four steps from commercial materials and (ii) a 6-exo-dig radical cyclization to forge the final piperidinyl ring system. This total synthesis of (+)-minfiensine was completed in nine chemical steps and 21% overall yield.
Original language | English (US) |
---|---|
Pages (from-to) | 13606-13607 |
Number of pages | 2 |
Journal | Journal of the American Chemical Society |
Volume | 131 |
Issue number | 38 |
DOIs | |
State | Published - 2009 |
All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Biochemistry
- Catalysis
- Colloid and Surface Chemistry