A nickel for your thoughts.ï̧ An enantioselective nickel-catalyzed cross-coupling between N-acylpyridinium salts and organozinc reagents is reported. The catalytic system, which is comprised of an air-stable NiII source and a chiral phosphoramidite ligand, affords 2-substituted-2,3-dihydro-4-pyridones with up to >99 % ee.
All Science Journal Classification (ASJC) codes
- Negishi reaction
- asymmetric catalysis
- nitrogen heterocycles