Nickel-catalyzed enantioselective arylation of pyridine

J. Patrick Lutz, Stephen T. Chau, Abigail G. Doyle

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


We report an enantioselective Ni-catalyzed cross coupling of arylzinc reagents with pyridinium ions formed in situ from pyridine and a chloroformate. This reaction provides enantioenriched 2-aryl-1,2-dihydropyridine products that can be elaborated to numerous piperidine derivatives with little or no loss in ee. This method is notable for its use of pyridine, a feedstock chemical, to build a versatile, chiral heterocycle in a single synthetic step.

Original languageEnglish (US)
Pages (from-to)4105-4109
Number of pages5
JournalChemical Science
Issue number7
StatePublished - 2016

All Science Journal Classification (ASJC) codes

  • General Chemistry


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