Nickel-catalyzed cross-coupling of styrenyl epoxides with boronic acids

Daniel K. Nielsen, Abigail Gutmann Doyle

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Let's get multicatalytic! A Ni 0 catalyst complexed with a biaryldialkyl monophosphine ligand facilitates C-C bond formation between styrenyl epoxides and aryl boronic acids (see scheme). X-ray analysis of a catalytically active nickel/ligand complex supports a redox pathway involving C sp 3-O bond activation. A variety of α-substituted alcohols were generated with good reaction efficiency by a multicatalytic sequence.

Original languageEnglish (US)
Pages (from-to)6056-6059
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number27
DOIs
StatePublished - Jun 27 2011

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Keywords

  • Suzuki-Miyaura reaction
  • cross-coupling
  • epoxides
  • multicatalytic reactions
  • nickel

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