Nickel catalyzed addition of organozincates to optically pure vinylic sulfoxides, synthesis of the phosphodiesterase IV inhibitor L-765,527 (CDP-840).

Ioannis N. Houpis, Audrey Molina, Ilias Dorziotis, Robert A. Reamer, R. P. Volante, Paul J. Reider

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Ph3lZnMgCl was added to the optically pure sulfoxide 3 in the presence of Ni(acac)2 to give, after desulfurization, the phosphodiesterase N inhibitor 1 in good yield and 92% enantiomeric excess.

Original languageEnglish (US)
Pages (from-to)7131-7134
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number41
DOIs
StatePublished - Oct 13 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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