Ph3lZnMgCl was added to the optically pure sulfoxide 3 in the presence of Ni(acac)2 to give, after desulfurization, the phosphodiesterase N inhibitor 1 in good yield and 92% enantiomeric excess.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Oct 13 1997|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry