Ni-catalyzed nucleophilic conjugate additions of Grignard and organozincate reagents to substituted 4-vinylpyridines. General synthesis of phosphodiesterase IV inhibitors

Ioannis N. Houpis, Jaemoon Lee, Ilias Dorziotis, Audrey Molina, Bob Reamer, R. P. Volante, Paul J. Reider

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Alkyl, aryl, and vinyl Grignard reagents were added to olefin II under Ni(acac)2 or Cl2Ni(PPh3)2 catalysis to give products with the general formula I in 74-95% yield. Organozincates gave similar results with Ni(acac)2 as the catalyst.

Original languageEnglish (US)
Pages (from-to)1185-1195
Number of pages11
JournalTetrahedron
Volume54
Issue number7
DOIs
StatePublished - Feb 12 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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