Ni-catalyzed nucleophilic conjugate additions of Grignard and organozincate reagents to substituted 4-vinylpyridines. General synthesis of phosphodiesterase IV inhibitors

Ioannis N. Houpis; Jaemoon Lee; Ilias Dorziotis; Audrey Molina; Bob Reamer; R. P. Volante; Paul J. Reider

doi:10.1016/S0040-4020(97)10217-4

Ni-catalyzed nucleophilic conjugate additions of Grignard and organozincate reagents to substituted 4-vinylpyridines. General synthesis of phosphodiesterase IV inhibitors

Ioannis N. Houpis, Jaemoon Lee, Ilias Dorziotis, Audrey Molina, Bob Reamer, R. P. Volante, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Alkyl, aryl, and vinyl Grignard reagents were added to olefin II under Ni(acac)₂ or Cl₂Ni(PPh₃)₂ catalysis to give products with the general formula I in 74-95% yield. Organozincates gave similar results with Ni(acac)₂ as the catalyst.

Original language	English (US)
Pages (from-to)	1185-1195
Number of pages	11
Journal	Tetrahedron
Volume	54
Issue number	7
DOIs	https://doi.org/10.1016/S0040-4020(97)10217-4
State	Published - Feb 12 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4020(97)10217-4

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title = "Ni-catalyzed nucleophilic conjugate additions of Grignard and organozincate reagents to substituted 4-vinylpyridines. General synthesis of phosphodiesterase IV inhibitors",

abstract = "Alkyl, aryl, and vinyl Grignard reagents were added to olefin II under Ni(acac)2 or Cl2Ni(PPh3)2 catalysis to give products with the general formula I in 74-95% yield. Organozincates gave similar results with Ni(acac)2 as the catalyst.",

author = "Houpis, {Ioannis N.} and Jaemoon Lee and Ilias Dorziotis and Audrey Molina and Bob Reamer and Volante, {R. P.} and Reider, {Paul J.}",

year = "1998",

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doi = "10.1016/S0040-4020(97)10217-4",

language = "English (US)",

volume = "54",

pages = "1185--1195",

journal = "Tetrahedron",

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T1 - Ni-catalyzed nucleophilic conjugate additions of Grignard and organozincate reagents to substituted 4-vinylpyridines. General synthesis of phosphodiesterase IV inhibitors

AU - Houpis, Ioannis N.

AU - Lee, Jaemoon

AU - Dorziotis, Ilias

AU - Molina, Audrey

AU - Reamer, Bob

AU - Volante, R. P.

AU - Reider, Paul J.

PY - 1998/2/12

Y1 - 1998/2/12

N2 - Alkyl, aryl, and vinyl Grignard reagents were added to olefin II under Ni(acac)2 or Cl2Ni(PPh3)2 catalysis to give products with the general formula I in 74-95% yield. Organozincates gave similar results with Ni(acac)2 as the catalyst.

AB - Alkyl, aryl, and vinyl Grignard reagents were added to olefin II under Ni(acac)2 or Cl2Ni(PPh3)2 catalysis to give products with the general formula I in 74-95% yield. Organozincates gave similar results with Ni(acac)2 as the catalyst.

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U2 - 10.1016/S0040-4020(97)10217-4

DO - 10.1016/S0040-4020(97)10217-4

M3 - Article

AN - SCOPUS:0032510191

SN - 0040-4020

VL - 54

SP - 1185

EP - 1195

JO - Tetrahedron

JF - Tetrahedron

IS - 7

ER -

Ni-catalyzed nucleophilic conjugate additions of Grignard and organozincate reagents to substituted 4-vinylpyridines. General synthesis of phosphodiesterase IV inhibitors

Abstract

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