New perspectives on dimensionality and variability from large-scale cortical dynamics

Tatiana A. Engel, Nicholas A. Steinmetz

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

The neocortex is a multi-scale network, with intricate local circuitry interwoven into a global mesh of long-range connections. Neural activity propagates within this network on a wide range of temporal and spatial scales. At the micro scale, neurophysiological recordings reveal coordinated dynamics in local neural populations, which support behaviorally relevant computations. At the macro scale, neuroimaging modalities measure global activity fluctuations organized into spatiotemporal patterns across the entire brain. Here we review recent advances linking the local and global scales of cortical dynamics and their relationship to behavior. We argue that diverse experimental observations on the dimensionality and variability of neural activity can be reconciled by considering how activity propagates in space and time on multiple spatial scales.

Original languageEnglish (US)
Pages (from-to)181-190
Number of pages10
JournalCurrent Opinion in Neurobiology
Volume58
DOIs
StatePublished - Oct 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience

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