TY - JOUR
T1 - New perspectives on dimensionality and variability from large-scale cortical dynamics
AU - Engel, Tatiana A.
AU - Steinmetz, Nicholas A.
N1 - Publisher Copyright:
© 2019 The Authors
PY - 2019/10
Y1 - 2019/10
N2 - The neocortex is a multi-scale network, with intricate local circuitry interwoven into a global mesh of long-range connections. Neural activity propagates within this network on a wide range of temporal and spatial scales. At the micro scale, neurophysiological recordings reveal coordinated dynamics in local neural populations, which support behaviorally relevant computations. At the macro scale, neuroimaging modalities measure global activity fluctuations organized into spatiotemporal patterns across the entire brain. Here we review recent advances linking the local and global scales of cortical dynamics and their relationship to behavior. We argue that diverse experimental observations on the dimensionality and variability of neural activity can be reconciled by considering how activity propagates in space and time on multiple spatial scales.
AB - The neocortex is a multi-scale network, with intricate local circuitry interwoven into a global mesh of long-range connections. Neural activity propagates within this network on a wide range of temporal and spatial scales. At the micro scale, neurophysiological recordings reveal coordinated dynamics in local neural populations, which support behaviorally relevant computations. At the macro scale, neuroimaging modalities measure global activity fluctuations organized into spatiotemporal patterns across the entire brain. Here we review recent advances linking the local and global scales of cortical dynamics and their relationship to behavior. We argue that diverse experimental observations on the dimensionality and variability of neural activity can be reconciled by considering how activity propagates in space and time on multiple spatial scales.
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U2 - 10.1016/j.conb.2019.09.003
DO - 10.1016/j.conb.2019.09.003
M3 - Review article
C2 - 31585331
AN - SCOPUS:85072724225
SN - 0959-4388
VL - 58
SP - 181
EP - 190
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -