New Insights into the Regulation of Epithelial-Mesenchymal Transition and Tissue Fibrosis

Kang Ae Lee, Celeste M. Nelson

Research output: Chapter in Book/Report/Conference proceedingChapter

120 Scopus citations

Abstract

Tissue fibrosis often presents as the final outcome of chronic disease and is a significant cause of morbidity and mortality worldwide. Fibrosis is driven by continuous expansion of fibroblasts and myofibroblasts. Epithelial-mesenchymal transition (EMT) is a form of cell plasticity in which epithelia acquire mesenchymal phenotypes and is increasingly recognized as an integral aspect of tissue fibrogenesis. In this review, we describe recent insight into the molecular and cellular factors that regulate EMT and its underlying signaling pathways. We also consider how mechanical cues from the microenvironment affect the regulation of EMT. Finally, we discuss the role of EMT in fibrotic diseases and propose approaches for detecting and treating fibrogenesis by targeting EMT.

Original languageEnglish (US)
Title of host publicationInternational Review of Cell and Molecular Biology
PublisherElsevier Inc.
Pages171-221
Number of pages51
DOIs
StatePublished - 2012

Publication series

NameInternational Review of Cell and Molecular Biology
Volume294
ISSN (Print)1937-6448

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Keywords

  • Epithelial plasticity
  • Epithelial-mesenchymal transition
  • Fibrosis
  • Mechanotransduction
  • Myofibroblasts
  • Pathogenesis

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  • Cite this

    Lee, K. A., & Nelson, C. M. (2012). New Insights into the Regulation of Epithelial-Mesenchymal Transition and Tissue Fibrosis. In International Review of Cell and Molecular Biology (pp. 171-221). (International Review of Cell and Molecular Biology; Vol. 294). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-394305-7.00004-5