New approach to the imidazolutidine moiety of MK-996

Chris H. Senanayake; Laura E. Fredenburgh; Robert A. Reamer; Ji Liu; F. Edward Roberts; Guy Humphrey; Andrew S. Thompson; Robert D. Larsen; Thomas R. Verhoeven; Paul J. Reider; Ichiro Shinkai

doi:10.3987/com-95-s91

New approach to the imidazolutidine moiety of MK-996

Chris H. Senanayake
, Laura E. Fredenburgh
, Robert A. Reamer
, Ji Liu
, F. Edward Roberts
, Guy Humphrey
, Andrew S. Thompson
, Robert D. Larsen
, Thomas R. Verhoeven
, Paul J. Reider
, Ichiro Shinkai

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A highly effective, regio-selective synthesis of imidazolutidine (1) is described starting from readily available malonamamidine hydrochloride and 2,4-pentanedione.

Original language	English (US)
Pages (from-to)	821-830
Number of pages	10
Journal	Heterocycles
Volume	42
Issue number	2
DOIs	https://doi.org/10.3987/com-95-s91
State	Published - 1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Pharmacology
Organic Chemistry

Access to Document

10.3987/com-95-s91

Cite this

@article{b008e3f3c1f5458aa4f4c3b71e16a06a,

title = "New approach to the imidazolutidine moiety of MK-996",

abstract = "A highly effective, regio-selective synthesis of imidazolutidine (1) is described starting from readily available malonamamidine hydrochloride and 2,4-pentanedione.",

author = "Senanayake, \{Chris H.\} and Fredenburgh, \{Laura E.\} and Reamer, \{Robert A.\} and Ji Liu and Roberts, \{F. Edward\} and Guy Humphrey and Thompson, \{Andrew S.\} and Larsen, \{Robert D.\} and Verhoeven, \{Thomas R.\} and Reider, \{Paul J.\} and Ichiro Shinkai",

year = "1996",

doi = "10.3987/com-95-s91",

language = "English (US)",

volume = "42",

pages = "821--830",

journal = "Heterocycles",

issn = "0385-5414",

publisher = "Japan Institute of Heterocyclic Chemistry",

number = "2",

}

TY - JOUR

T1 - New approach to the imidazolutidine moiety of MK-996

AU - Senanayake, Chris H.

AU - Fredenburgh, Laura E.

AU - Reamer, Robert A.

AU - Liu, Ji

AU - Roberts, F. Edward

AU - Humphrey, Guy

AU - Thompson, Andrew S.

AU - Larsen, Robert D.

AU - Verhoeven, Thomas R.

AU - Reider, Paul J.

AU - Shinkai, Ichiro

PY - 1996

Y1 - 1996

N2 - A highly effective, regio-selective synthesis of imidazolutidine (1) is described starting from readily available malonamamidine hydrochloride and 2,4-pentanedione.

AB - A highly effective, regio-selective synthesis of imidazolutidine (1) is described starting from readily available malonamamidine hydrochloride and 2,4-pentanedione.

UR - https://www.scopus.com/pages/publications/1542332574

UR - https://www.scopus.com/pages/publications/1542332574#tab=citedBy

U2 - 10.3987/com-95-s91

DO - 10.3987/com-95-s91

M3 - Article

AN - SCOPUS:1542332574

SN - 0385-5414

VL - 42

SP - 821

EP - 830

JO - Heterocycles

JF - Heterocycles

IS - 2

ER -

New approach to the imidazolutidine moiety of MK-996

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this