New approach to the imidazolutidine moiety of MK-996

Chris H. Senanayake; Laura E. Fredenburgh; Robert A. Reamer; Ji Liu; F. Edward Roberts; Guy Humphrey; Andrew S. Thompson; Robert D. Larsen; Thomas R. Verhoeven; Paul J. Reider; Ichiro Shinkai

doi:10.3987/com-95-s91

New approach to the imidazolutidine moiety of MK-996

Chris H. Senanayake, Laura E. Fredenburgh, Robert A. Reamer, Ji Liu, F. Edward Roberts, Guy Humphrey, Andrew S. Thompson, Robert D. Larsen, Thomas R. Verhoeven, Paul J. Reider, Ichiro Shinkai

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A highly effective, regio-selective synthesis of imidazolutidine (1) is described starting from readily available malonamamidine hydrochloride and 2,4-pentanedione.

Original language	English (US)
Pages (from-to)	821-830
Number of pages	10
Journal	Heterocycles
Volume	42
Issue number	2
DOIs	https://doi.org/10.3987/com-95-s91
State	Published - 1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Pharmacology
Organic Chemistry

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@article{b008e3f3c1f5458aa4f4c3b71e16a06a,

title = "New approach to the imidazolutidine moiety of MK-996",

abstract = "A highly effective, regio-selective synthesis of imidazolutidine (1) is described starting from readily available malonamamidine hydrochloride and 2,4-pentanedione.",

author = "Senanayake, \{Chris H.\} and Fredenburgh, \{Laura E.\} and Reamer, \{Robert A.\} and Ji Liu and Roberts, \{F. Edward\} and Guy Humphrey and Thompson, \{Andrew S.\} and Larsen, \{Robert D.\} and Verhoeven, \{Thomas R.\} and Reider, \{Paul J.\} and Ichiro Shinkai",

year = "1996",

doi = "10.3987/com-95-s91",

language = "English (US)",

volume = "42",

pages = "821--830",

journal = "Heterocycles",

issn = "0385-5414",

publisher = "Japan Institute of Heterocyclic Chemistry",

number = "2",

}

TY - JOUR

T1 - New approach to the imidazolutidine moiety of MK-996

AU - Senanayake, Chris H.

AU - Fredenburgh, Laura E.

AU - Reamer, Robert A.

AU - Liu, Ji

AU - Roberts, F. Edward

AU - Humphrey, Guy

AU - Thompson, Andrew S.

AU - Larsen, Robert D.

AU - Verhoeven, Thomas R.

AU - Reider, Paul J.

AU - Shinkai, Ichiro

PY - 1996

Y1 - 1996

N2 - A highly effective, regio-selective synthesis of imidazolutidine (1) is described starting from readily available malonamamidine hydrochloride and 2,4-pentanedione.

AB - A highly effective, regio-selective synthesis of imidazolutidine (1) is described starting from readily available malonamamidine hydrochloride and 2,4-pentanedione.

UR - https://www.scopus.com/pages/publications/1542332574

UR - https://www.scopus.com/inward/citedby.url?scp=1542332574&partnerID=8YFLogxK

U2 - 10.3987/com-95-s91

DO - 10.3987/com-95-s91

M3 - Article

AN - SCOPUS:1542332574

SN - 0385-5414

VL - 42

SP - 821

EP - 830

JO - Heterocycles

JF - Heterocycles

IS - 2

ER -

New approach to the imidazolutidine moiety of MK-996

Abstract

All Science Journal Classification (ASJC) codes

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