New approach to the imidazolutidine moiety of MK-996

Chris H. Senanayake, Laura E. Fredenburgh, Robert A. Reamer, Ji Liu, F. Edward Roberts, Guy Humphrey, Andrew S. Thompson, Robert D. Larsen, Thomas R. Verhoeven, Paul J. Reider, Ichiro Shinkai

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A highly effective, regio-selective synthesis of imidazolutidine (1) is described starting from readily available malonamamidine hydrochloride and 2,4-pentanedione.

Original languageEnglish (US)
Pages (from-to)821-830
Number of pages10
JournalHeterocycles
Volume42
Issue number2
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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