New approach to the imidazolutidine moiety of MK-996

Chris H. Senanayake, Laura E. Fredenburgh, Robert A. Reamer, Ji Liu, F. Edward Roberts, Guy Humphrey, Andrew S. Thompson, Robert D. Larsen, Thomas R. Verhoeven, Paul J. Reider, Ichiro Shinkai

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A highly effective, regio-selective synthesis of imidazolutidine (1) is described starting from readily available malonamamidine hydrochloride and 2,4-pentanedione.

Original languageEnglish (US)
Pages (from-to)821-830
Number of pages10
Issue number2
StatePublished - 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry


Dive into the research topics of 'New approach to the imidazolutidine moiety of MK-996'. Together they form a unique fingerprint.

Cite this