New air-stable catalysts for general and efficient Suzuki-Miyaura cross-coupling reactions of heteroaryl chlorides

Anil S. Guram; Anthony O. King; John G. Allen; Xianghong Wang; Laurie B. Schenkel; Johann Chan; Emilio E. Bunel; Margaret M. Faul; Robert D. Larsen; Michael J. Martinelli; Paul J. Reider

doi:10.1021/ol060268g

New air-stable catalysts for general and efficient Suzuki-Miyaura cross-coupling reactions of heteroaryl chlorides

Anil S. Guram
, Anthony O. King
, John G. Allen
, Xianghong Wang
, Laurie B. Schenkel
, Johann Chan
, Emilio E. Bunel
, Margaret M. Faul
, Robert D. Larsen
, Michael J. Martinelli
, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

183 Scopus citations

Abstract

New air-stable PdCl₂{ P^tBu₂(p-R-Ph)} ₂ (R = H, NMe₂, CF₃,) complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a diverse range of arylboronic acids. High product yields (89-99% isolated yields) and turn-over-numbers (10 000 TON) are observed.

Original language	English (US)
Pages (from-to)	1787-1789
Number of pages	3
Journal	Organic letters
Volume	8
Issue number	9
DOIs	https://doi.org/10.1021/ol060268g
State	Published - Apr 27 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol060268g

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@article{15e32a7eddbe48a18313e7e17f845ac6,

title = "New air-stable catalysts for general and efficient Suzuki-Miyaura cross-coupling reactions of heteroaryl chlorides",

abstract = "New air-stable PdCl2\{ PtBu2(p-R-Ph)\} 2 (R = H, NMe2, CF3,) complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a diverse range of arylboronic acids. High product yields (89-99\% isolated yields) and turn-over-numbers (10 000 TON) are observed.",

author = "Guram, \{Anil S.\} and King, \{Anthony O.\} and Allen, \{John G.\} and Xianghong Wang and Schenkel, \{Laurie B.\} and Johann Chan and Bunel, \{Emilio E.\} and Faul, \{Margaret M.\} and Larsen, \{Robert D.\} and Martinelli, \{Michael J.\} and Reider, \{Paul J.\}",

year = "2006",

month = apr,

day = "27",

doi = "10.1021/ol060268g",

language = "English (US)",

volume = "8",

pages = "1787--1789",

journal = "Organic letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "9",

}

TY - JOUR

T1 - New air-stable catalysts for general and efficient Suzuki-Miyaura cross-coupling reactions of heteroaryl chlorides

AU - Guram, Anil S.

AU - King, Anthony O.

AU - Allen, John G.

AU - Wang, Xianghong

AU - Schenkel, Laurie B.

AU - Chan, Johann

AU - Bunel, Emilio E.

AU - Faul, Margaret M.

AU - Larsen, Robert D.

AU - Martinelli, Michael J.

AU - Reider, Paul J.

PY - 2006/4/27

Y1 - 2006/4/27

N2 - New air-stable PdCl2{ PtBu2(p-R-Ph)} 2 (R = H, NMe2, CF3,) complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a diverse range of arylboronic acids. High product yields (89-99% isolated yields) and turn-over-numbers (10 000 TON) are observed.

AB - New air-stable PdCl2{ PtBu2(p-R-Ph)} 2 (R = H, NMe2, CF3,) complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a diverse range of arylboronic acids. High product yields (89-99% isolated yields) and turn-over-numbers (10 000 TON) are observed.

UR - https://www.scopus.com/pages/publications/33646464678

UR - https://www.scopus.com/pages/publications/33646464678#tab=citedBy

U2 - 10.1021/ol060268g

DO - 10.1021/ol060268g

M3 - Article

C2 - 16623551

AN - SCOPUS:33646464678

SN - 1523-7060

VL - 8

SP - 1787

EP - 1789

JO - Organic letters

JF - Organic letters

IS - 9

ER -

New air-stable catalysts for general and efficient Suzuki-Miyaura cross-coupling reactions of heteroaryl chlorides

Abstract

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