New air-stable catalysts for general and efficient Suzuki-Miyaura cross-coupling reactions of heteroaryl chlorides

Anil S. Guram, Anthony O. King, John G. Allen, Xianghong Wang, Laurie B. Schenkel, Johann Chan, Emilio E. Bunel, Margaret M. Faul, Robert D. Larsen, Michael J. Martinelli, Paul J. Reider

Research output: Contribution to journalArticlepeer-review

175 Scopus citations

Abstract

New air-stable PdCl2{ PtBu2(p-R-Ph)} 2 (R = H, NMe2, CF3,) complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a diverse range of arylboronic acids. High product yields (89-99% isolated yields) and turn-over-numbers (10 000 TON) are observed.

Original languageEnglish (US)
Pages (from-to)1787-1789
Number of pages3
JournalOrganic letters
Volume8
Issue number9
DOIs
StatePublished - Apr 27 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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