Neuroscience: Coupling between neuronal firing, field potentials, and fMRI in human auditory cortex

Roy Mukamel, Hagar Gelbard, Amos Arieli, Uri Hasson, Itzhak Fried, Rafael Malach

Research output: Contribution to journalArticlepeer-review

624 Scopus citations

Abstract

Functional magnetic resonance imaging (fMRI) is an important tool for investigating human brain function, but the relationship between the hemodynamically based fMRI signals in the human brain and the underlying neuronal activity is unclear. We recorded single unit activity and local field potentials in auditory cortex of two neurosurgical patients and compared them with the fMRI signals of 11 healthy subjects during presentation of an identical movie segment. The predicted fMRI signals derived from single units and the measured fMRI signals from auditory cortex showed a highly significant correlation (r = 0.75, P < 10-47). Thus, fMRI signals can provide a reliable measure of the firing rate of human cortical neurons.

Original languageEnglish (US)
Pages (from-to)951-954
Number of pages4
JournalScience
Volume309
Issue number5736
DOIs
StatePublished - Aug 5 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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