TY - JOUR
T1 - Neuronal plasticity and cellular immunity
T2 - Shared molecular mechanisms
AU - Boulanger, Lisa M.
AU - Huh, Gene S.
AU - Shatz, Carla J.
N1 - Funding Information:
We are very grateful to Patrick Kanold, Dan Butts, Josh Syken, and Linda Buck for critical reading of the manuscript. LM Boulanger is supported by a grant from the National Institutes of Health [1F32EY07016] and a Junior Fellowship from the Harvard Society of Fellows. GS Huh is supported by a fellowship from Damon Runyon–Walter Winchell Cancer Fund.
PY - 2001/10/1
Y1 - 2001/10/1
N2 - It is becoming evident that neurons express an unusual number of molecules that were originally thought to be specific to immune functions. One such molecule, class I major histocompatibility complex, is required in the activity-dependent refinement and plasticity of connections in the developing and adult central nervous system, demonstrating that molecules can perform critical roles in both systems. Recent studies reveal striking parallels between cellular signaling mechanisms in the immune and nervous systems that may provide unexpected insights into the development, function, and diseases of both systems.
AB - It is becoming evident that neurons express an unusual number of molecules that were originally thought to be specific to immune functions. One such molecule, class I major histocompatibility complex, is required in the activity-dependent refinement and plasticity of connections in the developing and adult central nervous system, demonstrating that molecules can perform critical roles in both systems. Recent studies reveal striking parallels between cellular signaling mechanisms in the immune and nervous systems that may provide unexpected insights into the development, function, and diseases of both systems.
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U2 - 10.1016/S0959-4388(00)00251-8
DO - 10.1016/S0959-4388(00)00251-8
M3 - Review article
C2 - 11595490
AN - SCOPUS:0035477393
VL - 11
SP - 568
EP - 578
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
IS - 5
ER -