Neuronal plasticity and cellular immunity: Shared molecular mechanisms

Lisa M. Boulanger, Gene S. Huh, Carla J. Shatz

Research output: Contribution to journalReview articlepeer-review

119 Scopus citations


It is becoming evident that neurons express an unusual number of molecules that were originally thought to be specific to immune functions. One such molecule, class I major histocompatibility complex, is required in the activity-dependent refinement and plasticity of connections in the developing and adult central nervous system, demonstrating that molecules can perform critical roles in both systems. Recent studies reveal striking parallels between cellular signaling mechanisms in the immune and nervous systems that may provide unexpected insights into the development, function, and diseases of both systems.

Original languageEnglish (US)
Pages (from-to)568-578
Number of pages11
JournalCurrent Opinion in Neurobiology
Issue number5
StatePublished - Oct 1 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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