Neurogenesis in adulthood: A posible role in learning

Elizabeth Gould, Patima Tanapat, Nicholas B. Hastings, Tracey J. Shors

Research output: Contribution to journalReview articlepeer-review

361 Scopus citations


The role of the hippocampal formation in learning and memory has long been recognized. However, despite decades of intensive research, the neurobiological basis of this process in the hippocampus remains enigmatic. Over 30 years ago, the production of new neurons was found to occur in the brains of adult rodents. More recently, the documentation of adult neurogenesis in the hippocampal formation of a variety of mammals, including humans, has suggested a novel approach towards understanding the biological bases of hippocampal function. Contemporary theories of hippocampal function include an important role for this brain region in associative learning. The addition of new neurons and consequently, their novel contribution to hippocampal circuitry could conceivably be a mechanism for relating spatially or temporally disparate events. In this review, we examine several lines of evidence suggesting that adult-generated neurons are involved in hippocampal- dependent learning. In particular, we examine the variables that modulate hippocampal neurogenesis in adulthood and their relation to learning and memory.

Original languageEnglish (US)
Pages (from-to)186-192
Number of pages7
JournalTrends in Cognitive Sciences
Issue number5
StatePublished - May 1 1999

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience


Dive into the research topics of 'Neurogenesis in adulthood: A posible role in learning'. Together they form a unique fingerprint.

Cite this