Neural characterization in partially observed populations of spiking neurons

Jonathan W. Pillow, Peter Latham

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Scopus citations

Abstract

Point process encoding models provide powerful statistical methods for understanding the responses of neurons to sensory stimuli. Although these models have been successfully applied to neurons in the early sensory pathway, they have fared less well capturing the response properties of neurons in deeper brain areas, owing in part to the fact that they do not take into account multiple stages of processing. Here we introduce a new twist on the point-process modeling approach: we include unobserved as well as observed spiking neurons in a joint encoding model. The resulting model exhibits richer dynamics and more highly nonlinear response properties, making it more powerful and more flexible for fitting neural data. More importantly, it allows us to estimate connectivity patterns among neurons (both observed and unobserved), and may provide insight into how networks process sensory input. We formulate the estimation procedure using variational EM and the wake-sleep algorithm, and illustrate the model's performance using a simulated example network consisting of two coupled neurons.

Original languageEnglish (US)
Title of host publicationAdvances in Neural Information Processing Systems 20 - Proceedings of the 2007 Conference
StatePublished - Dec 1 2009
Externally publishedYes
Event21st Annual Conference on Neural Information Processing Systems, NIPS 2007 - Vancouver, BC, Canada
Duration: Dec 3 2007Dec 6 2007

Publication series

NameAdvances in Neural Information Processing Systems 20 - Proceedings of the 2007 Conference

Other

Other21st Annual Conference on Neural Information Processing Systems, NIPS 2007
CountryCanada
CityVancouver, BC
Period12/3/0712/6/07

All Science Journal Classification (ASJC) codes

  • Information Systems

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  • Cite this

    Pillow, J. W., & Latham, P. (2009). Neural characterization in partially observed populations of spiking neurons. In Advances in Neural Information Processing Systems 20 - Proceedings of the 2007 Conference (Advances in Neural Information Processing Systems 20 - Proceedings of the 2007 Conference).