Neural and behavioral substrates of mood and mood regulation

Richard J. Davidson, David A. Lewis, Lauren B. Alloy, David G. Amaral, George Bush, Jonathan D. Cohen, Wayne C. Drevets, Martha J. Farah, Jerome Kagan, Jay L. McClelland, Susan Nolen-Hoeksema, Bradley S. Peterson

Research output: Contribution to journalReview articlepeer-review

307 Scopus citations


A review of behavioral and neurobiological data on mood and mood regulation as they pertain to an understanding of mood disorders is presented. Four approaches are considered: 1) behavioral and cognitive; 2) neurobiological; 3) computational; and 4) developmental. Within each of these four sections, we summarize the current status of the field and present our vision for the future, including particular challenges and opportunities. We conclude with a series of specific recommendations for National Institute of Mental Health priorities. Recommendations are presented for the behavioral domain, the neural domain, the domain of behavioral-neural interaction, for training, and for dissemination. It is in the domain of behavioral-neural interaction, in particular, that new research is required that brings together traditions that have developed relatively independently. Training interdisciplinary clinical scientists who meaningfully draw upon both behavioral and neuroscientific literatures and methods is critically required for the realization of these goals.

Original languageEnglish (US)
Pages (from-to)478-502
Number of pages25
JournalBiological Psychiatry
Issue number6
StatePublished - Sep 15 2002

All Science Journal Classification (ASJC) codes

  • Biological Psychiatry


  • Behavior
  • Mood
  • Mood disorders
  • Neurobiology


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