Neither methylating nor demethylating enzymes are required for bacterial chemotaxis

Jeff Stock, Greg Kersulis, Daniel E. Koshland

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Clarification of the information processing system in bacterial sensing has been obtained by studying mutants that lack the capacity to modify receptors covalently. The remaining part of the system is able to receive signals from the receptor, to respond with partial adaptation, and to exhibit a chemotactic response. A cycle of chemical reactions analogous to the rhodopsin-transducin cycle in the visual system is shown to provide the proper characteristics to serve as the bridge between receptor and chemotactic output, which allows adaptation in the absence of covalent protein modifications.

Original languageEnglish (US)
Pages (from-to)683-690
Number of pages8
Issue number2
StatePublished - Sep 1985

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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