Natural selection interacts with recombination to shape the evolution of hybrid genomes

Molly Schumer, Chenling Xu, Daniel L. Powell, Arun Durvasula, Laurits Skov, Chris Holland, John C. Blazier, Sriram Sankararaman, Peter Andolfatto, Gil G. Rosenthal, Molly Przeworski

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

To investigate the consequences of hybridization between species, we studied three replicate hybrid populations that formed naturally between two swordtail fish species, estimating their fine-scale genetic map and inferring ancestry along the genomes of 690 individuals. In all three populations, ancestry from the “minor” parental species is more common in regions of high recombination and where there is linkage to fewer putative targets of selection. The same patterns are apparent in a reanalysis of human and archaic admixture. These results support models in which ancestry from the minor parental species is more likely to persist when rapidly uncoupled from alleles that are deleterious in hybrids. Our analyses further indicate that selection on swordtail hybrids stems predominantly from deleterious combinations of epistatically interacting alleles.

Original languageEnglish (US)
Pages (from-to)656-660
Number of pages5
JournalScience
Volume360
Issue number6389
DOIs
StatePublished - May 11 2018

All Science Journal Classification (ASJC) codes

  • General

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    Schumer, M., Xu, C., Powell, D. L., Durvasula, A., Skov, L., Holland, C., Blazier, J. C., Sankararaman, S., Andolfatto, P., Rosenthal, G. G., & Przeworski, M. (2018). Natural selection interacts with recombination to shape the evolution of hybrid genomes. Science, 360(6389), 656-660. https://doi.org/10.1126/science.aar3684