Natural killer cells in psoriasis

A. M. Tobin; L. Lynch; B. Kirby; C. O'Farrelly

doi:10.1159/000328011

Natural killer cells in psoriasis

A. M. Tobin
, L. Lynch
, B. Kirby
, C. O'Farrelly

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known to be involved in psoriatic lesions, natural killer and natural killer T cells appear to have a unique role. We review the evidence supporting a role for natural killer cells in psoriasis.

Original language	English (US)
Pages (from-to)	403-410
Number of pages	8
Journal	Journal of Innate Immunity
Volume	3
Issue number	4
DOIs	https://doi.org/10.1159/000328011
State	Published - Jun 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy

Keywords

Innate immunity
Natural killer cells
Psoriasis

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10.1159/000328011

Cite this

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title = "Natural killer cells in psoriasis",

abstract = "Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known to be involved in psoriatic lesions, natural killer and natural killer T cells appear to have a unique role. We review the evidence supporting a role for natural killer cells in psoriasis.",

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T1 - Natural killer cells in psoriasis

AU - Tobin, A. M.

AU - Lynch, L.

AU - Kirby, B.

AU - O'Farrelly, C.

PY - 2011/6

Y1 - 2011/6

N2 - Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known to be involved in psoriatic lesions, natural killer and natural killer T cells appear to have a unique role. We review the evidence supporting a role for natural killer cells in psoriasis.

AB - Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known to be involved in psoriatic lesions, natural killer and natural killer T cells appear to have a unique role. We review the evidence supporting a role for natural killer cells in psoriasis.

KW - Innate immunity

KW - Natural killer cells

KW - Psoriasis

UR - https://www.scopus.com/pages/publications/80955180091

UR - https://www.scopus.com/pages/publications/80955180091#tab=citedBy

U2 - 10.1159/000328011

DO - 10.1159/000328011

M3 - Review article

C2 - 21613780

AN - SCOPUS:80955180091

SN - 1662-811X

VL - 3

SP - 403

EP - 410

JO - Journal of Innate Immunity

JF - Journal of Innate Immunity

IS - 4

ER -

Natural killer cells in psoriasis

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

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