Natural killer cells in psoriasis

A. M. Tobin, L. Lynch, B. Kirby, C. O'Farrelly

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known to be involved in psoriatic lesions, natural killer and natural killer T cells appear to have a unique role. We review the evidence supporting a role for natural killer cells in psoriasis.

Original languageEnglish (US)
Pages (from-to)403-410
Number of pages8
JournalJournal of Innate Immunity
Issue number4
StatePublished - Jun 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy


  • Innate immunity
  • Natural killer cells
  • Psoriasis


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