Nanoprecipitation of pharmaceuticals using mixing and block copolymer stabilization

Brian K. Johnson, Walid Saad, Robert K. Prud'homme

Research output: Chapter in Book/Report/Conference proceedingConference contribution

21 Scopus citations


A new technology to form nanoparticles of hydrophobic organic actives at high concentration and yield, and methods to characterize the process are presented. In the Flash Nano Precipitation process, an organic active and an amphiphilic diblock copolymer are dissolved in an organic phase and mixed rapidly with a miscible anti-solvent to trigger precipitation of the active with a narrow particle size distribution and controlled mean particle size (50-500 nm). The enabling components are a novel "analytical" (quantified mixing time) Confined Impinging Jets (CIJ) mixer for millisecond stream homogenization and amphiphilic diblock copolymers, which alter the organic nucleation and growth, provide steric stabilization for the particles, and offer a functional surface for the composite. Methods to quantify fundamental time scales of the process and their relation to component thermodynamics are provided. The technology is useful for applications in enhanced pharmaceutical delivery, dye preparation, and pesticide formulation.

Original languageEnglish (US)
Title of host publicationPolymeric Drug Delivery II Polymeric Matrices and Drug Particle Engineering
PublisherAmerican Chemical Society
Number of pages14
ISBN (Print)0841239185, 9780841239180
StatePublished - 2006

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Chemical Engineering


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