Nanomedicine as a non-invasive strategy for drug delivery across the blood brain barrier

Vivienne H. Tam, Chris Sosa, Rui Liu, Nan Yao, Rodney D. Priestley

Research output: Contribution to journalReview article

34 Scopus citations

Abstract

The blood brain barrier (BBB) is a major obstacle to drug delivery for diseases of the central nervous system (CNS). This brief review highlights the current invasive and non-invasive technologies available to address this problem. In particular, nanomedicine has shown much promise as a non-invasive strategy due to its drug loading capabilities, ease of targeting to the BBB, and small size. The versatility of this technology in terms of type of drug and imaging agent, carrier material, and targeting mechanism is highlighted in this review. The recent inclusion of imaging agents in the nanocarriers has important consequences for the field of theranostics.

Original languageEnglish (US)
Pages (from-to)331-342
Number of pages12
JournalInternational Journal of Pharmaceutics
Volume515
Issue number1-2
DOIs
StatePublished - Dec 30 2016

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Blood brain barrier
  • Drug delivery
  • Imaging
  • Nanomedicine
  • Theranostics

Fingerprint Dive into the research topics of 'Nanomedicine as a non-invasive strategy for drug delivery across the blood brain barrier'. Together they form a unique fingerprint.

  • Cite this