Nanogap detector inside nanofluidic channel for fast real-time label-free DNA analysis

Xiaogan Liang; Stephen Y. Chou

doi:10.1021/nl080473k

Nanogap detector inside nanofluidic channel for fast real-time label-free DNA analysis

Xiaogan Liang, Stephen Y. Chou

Research output: Contribution to journal › Article › peer-review

190 Scopus citations

Abstract

We report fabrication and characterization of a novel real-time, label-free DNA detector, that uses a long nanofluidic channel to stretch a DNA strand and a nanogap detector (with a gap as small as 9 nm) inside the channel to measure the electrical conduction perpendicular to the DNA backbone as it moves through the gap. We have observed electrical signals caused by 1.1 kilobase-pair (kbp) double-stranded (ds)-DNA passing through the gap in the nanogap detectors with a gap equal to or less than 13 nm.

Original language	English (US)
Pages (from-to)	1472-1476
Number of pages	5
Journal	Nano Letters
Volume	8
Issue number	5
DOIs	https://doi.org/10.1021/nl080473k
State	Published - May 2008

All Science Journal Classification (ASJC) codes

General Chemistry
Condensed Matter Physics
Mechanical Engineering
Bioengineering
General Materials Science

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10.1021/nl080473k

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abstract = "We report fabrication and characterization of a novel real-time, label-free DNA detector, that uses a long nanofluidic channel to stretch a DNA strand and a nanogap detector (with a gap as small as 9 nm) inside the channel to measure the electrical conduction perpendicular to the DNA backbone as it moves through the gap. We have observed electrical signals caused by 1.1 kilobase-pair (kbp) double-stranded (ds)-DNA passing through the gap in the nanogap detectors with a gap equal to or less than 13 nm.",

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AB - We report fabrication and characterization of a novel real-time, label-free DNA detector, that uses a long nanofluidic channel to stretch a DNA strand and a nanogap detector (with a gap as small as 9 nm) inside the channel to measure the electrical conduction perpendicular to the DNA backbone as it moves through the gap. We have observed electrical signals caused by 1.1 kilobase-pair (kbp) double-stranded (ds)-DNA passing through the gap in the nanogap detectors with a gap equal to or less than 13 nm.

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Nanogap detector inside nanofluidic channel for fast real-time label-free DNA analysis

Abstract

All Science Journal Classification (ASJC) codes

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