Nanogap detector inside nanofluidic channel for fast real-time label-free DNA analysis

Xiaogan Liang, Stephen Y. Chou

Research output: Contribution to journalArticle

167 Scopus citations

Abstract

We report fabrication and characterization of a novel real-time, label-free DNA detector, that uses a long nanofluidic channel to stretch a DNA strand and a nanogap detector (with a gap as small as 9 nm) inside the channel to measure the electrical conduction perpendicular to the DNA backbone as it moves through the gap. We have observed electrical signals caused by 1.1 kilobase-pair (kbp) double-stranded (ds)-DNA passing through the gap in the nanogap detectors with a gap equal to or less than 13 nm.

Original languageEnglish (US)
Pages (from-to)1472-1476
Number of pages5
JournalNano Letters
Volume8
Issue number5
DOIs
StatePublished - May 1 2008

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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