Nanofabricated upconversion nanoparticles for photodynamic therapy

Baris Ungun; Robert Krafft Prud'homme; Stephanie J. Budijono; Jingning Shan; Shuang Fang Lim; Yiguang Ju; Robert Hamilton Austin

doi:10.1364/OE.17.000080

Nanofabricated upconversion nanoparticles for photodynamic therapy

Baris Ungun
, Robert Krafft Prud'homme
, Stephanie J. Budijono
, Jingning Shan
, Shuang Fang Lim
, Yiguang Ju
, Robert Hamilton Austin

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

We present a novel process for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100-300 nm with an up-converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent clearance by the reticuloendothelial system. We show that these CNPs produce millimolar amounts of singlet oxygen at NIR intensities far less than other two-photon techniques.

Original language	English (US)
Pages (from-to)	80-86
Number of pages	7
Journal	Optics Express
Volume	17
Issue number	1
DOIs	https://doi.org/10.1364/OE.17.000080
State	Published - Jan 5 2009

All Science Journal Classification (ASJC) codes

Atomic and Molecular Physics, and Optics

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10.1364/OE.17.000080

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AU - Ungun, Baris

AU - Prud'homme, Robert Krafft

AU - Budijono, Stephanie J.

AU - Shan, Jingning

AU - Lim, Shuang Fang

AU - Ju, Yiguang

AU - Austin, Robert Hamilton

PY - 2009/1/5

Y1 - 2009/1/5

N2 - We present a novel process for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100-300 nm with an up-converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent clearance by the reticuloendothelial system. We show that these CNPs produce millimolar amounts of singlet oxygen at NIR intensities far less than other two-photon techniques.

AB - We present a novel process for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100-300 nm with an up-converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent clearance by the reticuloendothelial system. We show that these CNPs produce millimolar amounts of singlet oxygen at NIR intensities far less than other two-photon techniques.

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UR - https://www.scopus.com/pages/publications/58449100244#tab=citedBy

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JF - Optics Express

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ER -

Nanofabricated upconversion nanoparticles for photodynamic therapy

Abstract

All Science Journal Classification (ASJC) codes

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