Nanofabricated upconversion nanoparticles for photodynamic therapy

Baris Ungun, Robert Krafft Prud'homme, Stephanie J. Budijono, Jingning Shan, Shuang Fang Lim, Yiguang Ju, Robert Hamilton Austin

Research output: Contribution to journalArticlepeer-review

118 Scopus citations

Abstract

We present a novel process for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100-300 nm with an up-converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent clearance by the reticuloendothelial system. We show that these CNPs produce millimolar amounts of singlet oxygen at NIR intensities far less than other two-photon techniques.

Original languageEnglish (US)
Pages (from-to)80-86
Number of pages7
JournalOptics Express
Volume17
Issue number1
DOIs
StatePublished - Jan 5 2009

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics

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