Mutations affecting segment number and polarity in drosophila

Christiane Nüsslein-volhard; Eric Wieschaus

doi:10.1038/287795a0

Mutations affecting segment number and polarity in drosophila

Christiane Nüsslein-volhard, Eric Wieschaus

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Abstract

In systematic searches for embryonic lethal mutants of Drosophila melanogaster we have identified 15 loci which when mutated alter the segmental pattern of the larva. These loci probably represent the majority of such genes in Drosophila. The phenotypes of the mutant embryos indicate that the process of segmentation involves at least three levels of spatial organization: the entire egg as developmental unit, a repeat unit with the length of two segments, and the individual segment.

Original language	English (US)
Pages (from-to)	795-801
Number of pages	7
Journal	Nature
Volume	287
Issue number	5785
DOIs	https://doi.org/10.1038/287795a0
State	Published - 1980

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title = "Mutations affecting segment number and polarity in drosophila",

abstract = "In systematic searches for embryonic lethal mutants of Drosophila melanogaster we have identified 15 loci which when mutated alter the segmental pattern of the larva. These loci probably represent the majority of such genes in Drosophila. The phenotypes of the mutant embryos indicate that the process of segmentation involves at least three levels of spatial organization: the entire egg as developmental unit, a repeat unit with the length of two segments, and the individual segment.",

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AB - In systematic searches for embryonic lethal mutants of Drosophila melanogaster we have identified 15 loci which when mutated alter the segmental pattern of the larva. These loci probably represent the majority of such genes in Drosophila. The phenotypes of the mutant embryos indicate that the process of segmentation involves at least three levels of spatial organization: the entire egg as developmental unit, a repeat unit with the length of two segments, and the individual segment.

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Mutations affecting segment number and polarity in drosophila

Abstract

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