Mutations affecting segment number and polarity in drosophila

Christiane Nüsslein-volhard, Eric Wieschaus

Research output: Contribution to journalArticlepeer-review

3248 Scopus citations


In systematic searches for embryonic lethal mutants of Drosophila melanogaster we have identified 15 loci which when mutated alter the segmental pattern of the larva. These loci probably represent the majority of such genes in Drosophila. The phenotypes of the mutant embryos indicate that the process of segmentation involves at least three levels of spatial organization: the entire egg as developmental unit, a repeat unit with the length of two segments, and the individual segment.

Original languageEnglish (US)
Pages (from-to)795-801
Number of pages7
Issue number5785
StatePublished - 1980
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General


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