Mutational analysis of the lambda int gene: DNA sequence of dominant mutations.

S. E. Bear, J. B. Clemens, L. W. Enquist, R. J. Zagursky

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We have combined techniques of genetic and physical mapping with rapid DNA sequence analysis to identify the nucleotide change in lambda int mutations. These mutations define two dominant phenotypic classes: (i) recombination that is partially independent of accessory factors, and (ii) inhibition of wild-type Int by missense or nonsense proteins, i.e., negative complementation.

Original languageEnglish (US)
Pages (from-to)5880-5883
Number of pages4
JournalJournal of bacteriology
Volume169
Issue number12
DOIs
StatePublished - Dec 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

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