Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.

M. R. Rubin, W. King, L. E. Toth, I. S. Sawczuk, M. S. Levine, P. D'Eustachio, M. C. Nguyen-Huu

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


A new murine homeo-box, called Hox-1.7, has been identified in a rare cDNA from F9 teratocarcinoma stem cells. The Hox-1.7 homeo-box is 68 and 72% homologous to the Drosophila antennapedia (Antp) and iab-7 homeo-boxes, respectively. A major 2.5-kilobase transcript and several minor transcripts were detected by Northern blot (RNA blot) analysis in adult tissues as well as in midgestational embryos. The posterior spinal cord was found to be a major site of Hox-1.7 expression in 12.5-day-old embryos. Somatic cell hybrids were used to map the Hox-1.7 gene to mouse chromosome 6. Restriction fragment length polymorphisms associated with either the Hox-1.7 gene or the previously known Hox-1 complex were identified. Their distribution patterns in recombinant inbred mouse strains were used to determine the linkage between the two loci as well as to other loci on chromosome 6. This maps Hox-1 and Hox-1.7 close to two mouse loci that affect morphogenesis, postaxial hemimelia (px) and hypodactyly (Hd).

Original languageEnglish (US)
Pages (from-to)3836-3841
Number of pages6
JournalMolecular and cellular biology
Issue number10
StatePublished - Oct 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology


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