Multiple cis-acting targeting sequences are required for orb mRNA localization during Drosophila oogenesis

Valerie Lantz, Paul Schedl

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The targeting of positional information to specific regions of the oocyte or early embryo is one of the key processes in establishing anterior- posterior and dorsal-ventral polarity. In many developmental systems, this is accomplished by localization of mRNAs. The germ line-specific Drosophila orb gene plays a critical role in defining both axes of the developing oocyte, and its mRNA is localized in a complex pattern during oogenesis. We have identified a 280-bp sequence from the orb 3' untranslated region capable of reproducing this complex localization pattern. Furthermore, we have found that multiple cis-acting elements appear to be required for proper targeting of orb mRNA.

Original languageEnglish (US)
Pages (from-to)2235-2242
Number of pages8
JournalMolecular and cellular biology
Volume14
Issue number4
DOIs
StatePublished - Apr 1994

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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