Multi-wavelength resonance Raman spectroscopy of bacteria to study the effects of growth condition

  • Nagapratima Kunapareddy
  • , Jacob Grun
  • , Robert Lunsford
  • , David Gillis
  • , Sergei Nikitin
  • , Zheng Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We will examine the use of multi-wavelength UV resonance-Raman signatures to identify the effects of growth phase on different types of bacteria. Gram positive and gram-negative species, Escherichia coli, Bacillus cereus, Citrobacter koseri and Citrobacter braakii were grown to logarithmic and stationary phases in different culture media. Raman spectra of bacteria were obtained by sequential illumination of samples between 220 and 260 nm; a range which encompasses the resonance frequencies of cellular components. In addition to the information contained in the single spectrum, this two-dimensional signature contains information reflecting variations in resonance cross sections with illumination wavelength. Results of our algorithms in identifying the differences between these germs are discussed. Preliminary results indicate that growth affects the Raman signature, but not to an extent that would negate identification of the species.

Original languageEnglish (US)
Title of host publicationChemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XIII
PublisherSPIE
ISBN (Print)9780819490360
DOIs
StatePublished - 2012
Externally publishedYes
EventChemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XIII - Baltimore, MD, United States
Duration: Apr 24 2012Apr 27 2012

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume8358
ISSN (Print)0277-786X

Other

OtherChemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XIII
Country/TerritoryUnited States
CityBaltimore, MD
Period4/24/124/27/12

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Keywords

  • Bacteria identification
  • Multi-wavelength spectroscopy
  • Resonance Raman spectroscopy
  • UV

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