@article{731ad5aacff74a9b9e77024aa9cfd4af,
title = "MTDH Activation by 8q22 Genomic Gain Promotes Chemoresistance and Metastasis of Poor-Prognosis Breast Cancer",
abstract = "Targeted therapy for metastatic diseases relies on the identification of functionally important metastasis genes from a large number of random genetic alterations. Here we use a computational algorithm to map minimal recurrent genomic alterations associated with poor-prognosis breast cancer. 8q22 genomic gain was identified by this approach and validated in an extensive collection of breast tumor samples. Regional gain of 8q22 elevates expression of the metastasis gene metadherin (MTDH), which is overexpressed in more than 40% of breast cancers and is associated with poor clinical outcomes. Functional characterization of MTDH revealed its dual role in promoting metastatic seeding and enhancing chemoresistance. These findings establish MTDH as an important therapeutic target for simultaneously enhancing chemotherapy efficacy and reducing metastasis risk.",
author = "Guohong Hu and Chong, {Robert A.} and Qifeng Yang and Yong Wei and Blanco, {Mario A.} and Feng Li and Michael Reiss and Au, {Jessie L.S.} and Haffty, {Bruce G.} and Yibin Kang",
note = "Funding Information: We thank J. Massagu{\'e}, D. Botstein, S. Tavazoie, Y. Shi, and O. Matveeva for insightful discussions and technical suggestions; L.M. Staudt for the pRSMX vector; C.J. Kirkpatrick for the STA cell line; L. Cong, J. Friedman, and L. Goodell at the Tissue Analytic Services Shared Resource of the Cancer Institute of New Jersey for assistance with immunohistochemistry analysis of tissue arrays; and Y. Xiao, K. Jones, and C. Lee at the Dana-Farber Cancer Institute Cytogenetics Core for FISH analysis. Y.K. was funded by a Department of Defense Era of Hope Scholar Award and grants from the NIH (R01CA134519), the American Cancer Society, the Susan G. Komen Foundation, and the New Jersey Commission on Cancer Research. G.H. is supported by a postdoctoral fellowship from the New Jersey Commission on Cancer Research. ",
year = "2009",
month = jan,
day = "6",
doi = "10.1016/j.ccr.2008.11.013",
language = "English (US)",
volume = "15",
pages = "9--20",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "1",
}