@article{29bd91b5debe4b83864e32ff9cebb4b7,
title = "Mouse ooplasm confers context-specific reprogramming capacity",
abstract = "Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes.",
author = "Chan, {Michelle M.} and Smith, {Zachary D.} and Dieter Egli and Aviv Regev and Alexander Meissner",
note = "Funding Information: We would like to thank all the members of the Meissner and Regev laboratories. We thank M. Garber, N. Yosef, J. Ye, R. Koche, H. Gu, A. Gnirke and T. Mikkelsen for technical advice and discussion and all members of the Broad Sequencing Platform, in particular, F. Kelley, J. Meldrim, T. Fennel, K. Tibbetts and J. Fostel. We also thank S. Levine, M. Gravina and K. Thai from the MIT BioMicro Center. D.E. is supported by the New York Stem Cell Foundation (NYSCF). A.R. is an investigator of the Merkin Foundation for Stem Cell Research at the Broad Institute and is supported by a US National Institutes of Health (NIH) Pioneer Award (5DP1OD003958), a National Human Genome Research Institute (NHGRI) Centers of Excellence in Genomic Science (CEGS) grant (1P50HG006193), the Burroughs Wellcome Career Award at the Scientific Interface and the Howard Hughes Medical Institute (HHMI). A.M. is supported by the Pew Charitable Trusts, the Human Frontiers Science Program and the NIH (U01ES017155, P01GM099117 and 1P50HG006193).",
year = "2012",
month = sep,
doi = "10.1038/ng.2382",
language = "English (US)",
volume = "44",
pages = "978--980",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Research",
number = "9",
}