Mouse ooplasm confers context-specific reprogramming capacity

Michelle M. Chan, Zachary D. Smith, Dieter Egli, Aviv Regev, Alexander Meissner

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes.

Original languageEnglish (US)
Pages (from-to)978-980
Number of pages3
JournalNature Genetics
Volume44
Issue number9
DOIs
StatePublished - Sep 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics

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