@inbook{0925321913994d5d87b6ee041ec32bf6,
title = "Mouse models for studying HCV vaccines and therapeutic antibodies",
abstract = "In spite of the immense progress in hepatitis C virus (HCV) research, efforts to prevent infection, such as generating a vaccine, have not yet been successful. The high price tag associated with current treatment options for chronic infection and the spike in new infections concurrent with growing opioid abuse are strong motivators for developing effective immunization and understanding neutralizing antibodies{\textquoteright} role in preventing infection. Humanized mice—both human liver chimeras as well as genetically humanized models—are important platforms for testing both possible vaccine candidates as well as antibody-based therapies. This chapter details the variety of ways humanized mouse technology can be employed in pursuit of learning how HCV infection can be prevented.",
keywords = "Hepatitis C virus, Humanized mice, Immunization, Neutralizing antibodies",
author = "Gaska, {Jenna M.} and Qiang Ding and Alexander Ploss",
note = "Funding Information: This study is supported by grants from the National Institutes of Health (R01 AI079031, R01 AI107301, R21AI117213 to A.P.), a Research Scholar Award from the American Cancer Society (RSG-15-048-01-MPC to A.P.), a Burroughs Wellcome Fund Award for Investigators in Pathogenesis (to A.P.) and funds from Princeton University. J.M.G. was in part supported by cofunding from NIAID on iNRSA 5T32GM00738 and Q.D. by a postdoctoral fellowship from the New Jersey Commission on Cancer Research. Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2019.",
year = "2019",
doi = "10.1007/978-1-4939-8976-8_33",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "481--503",
booktitle = "Methods in Molecular Biology",
}