Mouse genomic screen reveals novel host regulator of metastasis

Toni Celiï¿½-Terrassa; Yibin Kang

doi:10.1186/s13059-017-1170-x

Mouse genomic screen reveals novel host regulator of metastasis

Toni Celiï¿½-Terrassa, Yibin Kang

Molecular Biology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune-mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastatic colonization.

Original language	English (US)
Article number	31
Journal	Genome Biology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s13059-017-1170-x
State	Published - Feb 16 2017

All Science Journal Classification (ASJC) codes

Ecology, Evolution, Behavior and Systematics
Genetics
Cell Biology

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10.1186/s13059-017-1170-x

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title = "Mouse genomic screen reveals novel host regulator of metastasis",

abstract = "Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune-mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastatic colonization.",

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AB - Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune-mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastatic colonization.

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Mouse genomic screen reveals novel host regulator of metastasis

Abstract

All Science Journal Classification (ASJC) codes

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