Mouse genomic screen reveals novel host regulator of metastasis

Toni Celi�-Terrassa, Yibin Kang

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune-mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastatic colonization.

Original languageEnglish (US)
Article number31
JournalGenome Biology
Volume18
Issue number1
DOIs
StatePublished - Feb 16 2017

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

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