TY - JOUR
T1 - Molecular tools for imaging and recording neuronal activity
AU - Wang, Wenjing
AU - Kim, Christina K.
AU - Ting, Alice Y.
N1 - Publisher Copyright:
© 2019, Springer Nature America, Inc.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - To understand how the brain relates to behavior, it is essential to record neural activity in awake, behaving animals. To achieve this goal, a large variety of genetically encoded sensors have been developed to monitor and record the series of events following neuronal firing, including action potentials, intracellular calcium rise, neurotransmitter release and immediate early gene expression. In this Review, we discuss the existing genetically encoded tools for detecting and integrating neuronal activity in animals and highlight the remaining challenges and future opportunities for molecular biologists.
AB - To understand how the brain relates to behavior, it is essential to record neural activity in awake, behaving animals. To achieve this goal, a large variety of genetically encoded sensors have been developed to monitor and record the series of events following neuronal firing, including action potentials, intracellular calcium rise, neurotransmitter release and immediate early gene expression. In this Review, we discuss the existing genetically encoded tools for detecting and integrating neuronal activity in animals and highlight the remaining challenges and future opportunities for molecular biologists.
UR - http://www.scopus.com/inward/record.url?scp=85060140860&partnerID=8YFLogxK
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U2 - 10.1038/s41589-018-0207-0
DO - 10.1038/s41589-018-0207-0
M3 - Review article
C2 - 30659298
AN - SCOPUS:85060140860
SN - 1552-4450
VL - 15
SP - 101
EP - 110
JO - Nature Chemical Biology
JF - Nature Chemical Biology
IS - 2
ER -