Molecular mechanisms of agr quorum sensing in virulent staphylococci

Elizabeth A. George, Tom W. Muir

Research output: Contribution to journalShort surveypeer-review

128 Scopus citations


(Figure Presented) How to become virulent. The staphylococcal accessory gene-regulator (agr) quorum-sensing system is responsible for integrating growth-dependent signals with a complex genetic network to coordinate expression of a large variety of virulence factors. Our current understanding of the molecular mechanisms of agr activation and inhibition are described, along with implications for the in vivo role of agr in pathogenesis.

Original languageEnglish (US)
Pages (from-to)847-855
Number of pages9
Issue number8
StatePublished - May 25 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Biochemistry
  • Organic Chemistry


  • Accessory gene regulator
  • Autoinducers
  • Kinases
  • Quorum sensing
  • Virulence factors


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