Molecular mechanisms of agr quorum sensing in virulent staphylococci

Elizabeth A. George; Tom W. Muir

doi:10.1002/cbic.200700023

Molecular mechanisms of agr quorum sensing in virulent staphylococci

Elizabeth A. George, Tom W. Muir

Research output: Contribution to journal › Short survey › peer-review

130 Scopus citations

Abstract

(Figure Presented) How to become virulent. The staphylococcal accessory gene-regulator (agr) quorum-sensing system is responsible for integrating growth-dependent signals with a complex genetic network to coordinate expression of a large variety of virulence factors. Our current understanding of the molecular mechanisms of agr activation and inhibition are described, along with implications for the in vivo role of agr in pathogenesis.

Original language	English (US)
Pages (from-to)	847-855
Number of pages	9
Journal	ChemBioChem
Volume	8
Issue number	8
DOIs	https://doi.org/10.1002/cbic.200700023
State	Published - May 25 2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Medicine
Molecular Biology
Biochemistry
Organic Chemistry

Keywords

Accessory gene regulator
Autoinducers
Kinases
Quorum sensing
Virulence factors

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10.1002/cbic.200700023

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abstract = "(Figure Presented) How to become virulent. The staphylococcal accessory gene-regulator (agr) quorum-sensing system is responsible for integrating growth-dependent signals with a complex genetic network to coordinate expression of a large variety of virulence factors. Our current understanding of the molecular mechanisms of agr activation and inhibition are described, along with implications for the in vivo role of agr in pathogenesis.",

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AU - George, Elizabeth A.

AU - Muir, Tom W.

PY - 2007/5/25

Y1 - 2007/5/25

N2 - (Figure Presented) How to become virulent. The staphylococcal accessory gene-regulator (agr) quorum-sensing system is responsible for integrating growth-dependent signals with a complex genetic network to coordinate expression of a large variety of virulence factors. Our current understanding of the molecular mechanisms of agr activation and inhibition are described, along with implications for the in vivo role of agr in pathogenesis.

AB - (Figure Presented) How to become virulent. The staphylococcal accessory gene-regulator (agr) quorum-sensing system is responsible for integrating growth-dependent signals with a complex genetic network to coordinate expression of a large variety of virulence factors. Our current understanding of the molecular mechanisms of agr activation and inhibition are described, along with implications for the in vivo role of agr in pathogenesis.

KW - Accessory gene regulator

KW - Autoinducers

KW - Kinases

KW - Quorum sensing

KW - Virulence factors

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DO - 10.1002/cbic.200700023

M3 - Short survey

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IS - 8

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Molecular mechanisms of agr quorum sensing in virulent staphylococci

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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