Molecular biological constraints on ligand-binding affinity and specificity

Danuta Szwajkajzer; Jannette Carey

doi:10.1002/(SICI)1097-0282(1997)44:2<181::AID-BIP5>3.0.CO;2-R

Molecular biological constraints on ligand-binding affinity and specificity

Danuta Szwajkajzer
, Jannette Carey

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Interactions between biological macromolecules have characteristic values of affinity and specificity that are set according to the biological function that is served by the interaction in the organism. Here we examine the molecular mechanisms that are used to achieve the required values of affinity and specificity in various biological systems.

Original language	English (US)
Pages (from-to)	181-198
Number of pages	18
Journal	Biopolymers
Volume	44
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1097-0282(1997)44:2<181::AID-BIP5>3.0.CO;2-R
State	Published - 1997

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Biomaterials
Organic Chemistry

Keywords

Adaptability
Additivity
Host-guest chemistry
Intermolecular interactions
Preorganization
Rational drug design

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10.1002/(SICI)1097-0282(1997)44:2<181::AID-BIP5>3.0.CO;2-R

Cite this

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title = "Molecular biological constraints on ligand-binding affinity and specificity",

abstract = "Interactions between biological macromolecules have characteristic values of affinity and specificity that are set according to the biological function that is served by the interaction in the organism. Here we examine the molecular mechanisms that are used to achieve the required values of affinity and specificity in various biological systems.",

keywords = "Adaptability, Additivity, Host-guest chemistry, Intermolecular interactions, Preorganization, Rational drug design",

author = "Danuta Szwajkajzer and Jannette Carey",

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AU - Szwajkajzer, Danuta

AU - Carey, Jannette

PY - 1997

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AB - Interactions between biological macromolecules have characteristic values of affinity and specificity that are set according to the biological function that is served by the interaction in the organism. Here we examine the molecular mechanisms that are used to achieve the required values of affinity and specificity in various biological systems.

KW - Adaptability

KW - Additivity

KW - Host-guest chemistry

KW - Intermolecular interactions

KW - Preorganization

KW - Rational drug design

UR - https://www.scopus.com/pages/publications/0030783569

UR - https://www.scopus.com/pages/publications/0030783569#tab=citedBy

U2 - 10.1002/(SICI)1097-0282(1997)44:2<181::AID-BIP5>3.0.CO;2-R

DO - 10.1002/(SICI)1097-0282(1997)44:2<181::AID-BIP5>3.0.CO;2-R

M3 - Article

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AN - SCOPUS:0030783569

SN - 0006-3525

VL - 44

SP - 181

EP - 198

JO - Biopolymers

JF - Biopolymers

IS - 2

ER -

Molecular biological constraints on ligand-binding affinity and specificity

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

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