Molecular biological constraints on ligand-binding affinity and specificity

Danuta Szwajkajzer, Jannette Carey

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Interactions between biological macromolecules have characteristic values of affinity and specificity that are set according to the biological function that is served by the interaction in the organism. Here we examine the molecular mechanisms that are used to achieve the required values of affinity and specificity in various biological systems.

Original languageEnglish (US)
Pages (from-to)181-198
Number of pages18
JournalBiopolymers
Volume44
Issue number2
DOIs
StatePublished - Jan 1 1997

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry

Keywords

  • Adaptability
  • Additivity
  • Host-guest chemistry
  • Intermolecular interactions
  • Preorganization
  • Rational drug design

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