Molecular architecture of the complete COG tethering complex

Jun Yong Ha, Hui Ting Chou, Daniel Ungar, Calvin K. Yip, Thomas Walz, Frederick M. Hughson

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


The conserved oligomeric Golgi (COG) complex orchestrates vesicular trafficking to and within the Golgi apparatus. Here, we use negative-stain electron microscopy to elucidate the architecture of the hetero-octameric COG complex from Saccharomyces cerevisiae. Intact COG has an intricate shape, with four (or possibly five) flexible legs, that differs strikingly from that of the exocyst complex and appears to be well suited for vesicle capture and fusion.

Original languageEnglish (US)
Pages (from-to)758-760
Number of pages3
JournalNature Structural and Molecular Biology
Issue number8
StatePublished - Aug 1 2016

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Structural Biology


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