Molecular architecture of the complete COG tethering complex

Jun Yong Ha; Hui Ting Chou; Daniel Ungar; Calvin K. Yip; Thomas Walz; Frederick M. Hughson

doi:10.1038/nsmb.3263

Molecular architecture of the complete COG tethering complex

Jun Yong Ha, Hui Ting Chou, Daniel Ungar, Calvin K. Yip, Thomas Walz, Frederick M. Hughson

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31 Scopus citations

Abstract

The conserved oligomeric Golgi (COG) complex orchestrates vesicular trafficking to and within the Golgi apparatus. Here, we use negative-stain electron microscopy to elucidate the architecture of the hetero-octameric COG complex from Saccharomyces cerevisiae. Intact COG has an intricate shape, with four (or possibly five) flexible legs, that differs strikingly from that of the exocyst complex and appears to be well suited for vesicle capture and fusion.

Original language	English (US)
Pages (from-to)	758-760
Number of pages	3
Journal	Nature Structural and Molecular Biology
Volume	23
Issue number	8
DOIs	https://doi.org/10.1038/nsmb.3263
State	Published - Aug 1 2016

All Science Journal Classification (ASJC) codes

Molecular Biology
Structural Biology

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AU - Walz, Thomas

AU - Hughson, Frederick M.

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Molecular architecture of the complete COG tethering complex

Abstract

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