Modulations of histone messenger RNA during the early development of Xenopus laevis

J. V. Ruderman, H. R. Woodland, E. A. Sturgess

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

The amount of translatable histone mRNA in Xenopus oocytes, eggs, and embryos was found to be roughly similar, as judged by a cell-free translation assay. This observation provides further evidence that posttranscriptional control mechanisms bring about the 50-fold increase in the rate of histone synthesis during oocyte maturation. About three-quarters of the oocyte histone mRNA was found to be polyadenylated. However, polyadenylated histone mRNA was scarcely detectable in the egg and embryo. Our data are consistent with the speculation presented here that the disappearance of the poly(A)+ histone mRNA component at the time of conversion of oocyte to egg (maturation) is due to deadenylation.

Original languageEnglish (US)
Pages (from-to)71-82
Number of pages12
JournalDevelopmental biology
Volume71
Issue number1
DOIs
StatePublished - Jul 1979
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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