Modulating Vibrio cholerae Quorum-Sensing-Controlled Communication Using Autoinducer-Loaded Nanoparticles

Hoang D. Lu; Alina C. Spiegel; Amanda Hurley; Lark J. Perez; Katharina Maisel; Laura M. Ensign; Justin Hanes; Bonnie Lynn Bassler; Martin F. Semmelhack; Robert Krafft Prud'homme

doi:10.1021/acs.nanolett.5b00151

Modulating Vibrio cholerae Quorum-Sensing-Controlled Communication Using Autoinducer-Loaded Nanoparticles

Hoang D. Lu, Alina C. Spiegel, Amanda Hurley, Lark J. Perez, Katharina Maisel, Laura M. Ensign, Justin Hanes, Bonnie Lynn Bassler, Martin F. Semmelhack, Robert Krafft Prud'homme

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The rise of bacterial antibiotic resistance has created a demand for alternatives to traditional antibiotics. Attractive possibilities include pro- and anti-quorum sensing therapies that function by modulating bacterial chemical communication circuits. We report the use of Flash NanoPrecipitation to deliver the Vibrio cholerae quorum-sensing signal CAI-1 ((S)-3-hydroxytridecan-4-one) in a water dispersible form as nanoparticles. The particles activate V. cholerae quorum-sensing responses 5 orders of magnitude higher than does the identically administered free CAI-1 and are diffusive across in vivo delivery barriers such as intestinal mucus. This work highlights the promise of combining quorum-sensing strategies with drug delivery approaches for the development of next-generation medicines.

Original language	English (US)
Pages (from-to)	2235-2241
Number of pages	7
Journal	Nano Letters
Volume	15
Issue number	4
DOIs	https://doi.org/10.1021/acs.nanolett.5b00151
State	Published - Apr 8 2015

All Science Journal Classification (ASJC) codes

General Chemistry
Condensed Matter Physics
Mechanical Engineering
Bioengineering
General Materials Science

Keywords

CAI-1
Nanoparticle
Vibrio cholerae
autoinducer
drug delivery
quorum sensing

Access to Document

10.1021/acs.nanolett.5b00151

Cite this

@article{8bec505a54e54d31bae302a096e72c8e,

title = "Modulating Vibrio cholerae Quorum-Sensing-Controlled Communication Using Autoinducer-Loaded Nanoparticles",

abstract = "The rise of bacterial antibiotic resistance has created a demand for alternatives to traditional antibiotics. Attractive possibilities include pro- and anti-quorum sensing therapies that function by modulating bacterial chemical communication circuits. We report the use of Flash NanoPrecipitation to deliver the Vibrio cholerae quorum-sensing signal CAI-1 ((S)-3-hydroxytridecan-4-one) in a water dispersible form as nanoparticles. The particles activate V. cholerae quorum-sensing responses 5 orders of magnitude higher than does the identically administered free CAI-1 and are diffusive across in vivo delivery barriers such as intestinal mucus. This work highlights the promise of combining quorum-sensing strategies with drug delivery approaches for the development of next-generation medicines.",

keywords = "CAI-1, Nanoparticle, Vibrio cholerae, autoinducer, drug delivery, quorum sensing",

author = "Lu, {Hoang D.} and Spiegel, {Alina C.} and Amanda Hurley and Perez, {Lark J.} and Katharina Maisel and Ensign, {Laura M.} and Justin Hanes and Bassler, {Bonnie Lynn} and Semmelhack, {Martin F.} and Prud'homme, {Robert Krafft}",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

month = apr,

day = "8",

doi = "10.1021/acs.nanolett.5b00151",

language = "English (US)",

volume = "15",

pages = "2235--2241",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "4",

}

TY - JOUR

T1 - Modulating Vibrio cholerae Quorum-Sensing-Controlled Communication Using Autoinducer-Loaded Nanoparticles

AU - Lu, Hoang D.

AU - Spiegel, Alina C.

AU - Hurley, Amanda

AU - Perez, Lark J.

AU - Maisel, Katharina

AU - Ensign, Laura M.

AU - Hanes, Justin

AU - Bassler, Bonnie Lynn

AU - Semmelhack, Martin F.

AU - Prud'homme, Robert Krafft

PY - 2015/4/8

Y1 - 2015/4/8

N2 - The rise of bacterial antibiotic resistance has created a demand for alternatives to traditional antibiotics. Attractive possibilities include pro- and anti-quorum sensing therapies that function by modulating bacterial chemical communication circuits. We report the use of Flash NanoPrecipitation to deliver the Vibrio cholerae quorum-sensing signal CAI-1 ((S)-3-hydroxytridecan-4-one) in a water dispersible form as nanoparticles. The particles activate V. cholerae quorum-sensing responses 5 orders of magnitude higher than does the identically administered free CAI-1 and are diffusive across in vivo delivery barriers such as intestinal mucus. This work highlights the promise of combining quorum-sensing strategies with drug delivery approaches for the development of next-generation medicines.

AB - The rise of bacterial antibiotic resistance has created a demand for alternatives to traditional antibiotics. Attractive possibilities include pro- and anti-quorum sensing therapies that function by modulating bacterial chemical communication circuits. We report the use of Flash NanoPrecipitation to deliver the Vibrio cholerae quorum-sensing signal CAI-1 ((S)-3-hydroxytridecan-4-one) in a water dispersible form as nanoparticles. The particles activate V. cholerae quorum-sensing responses 5 orders of magnitude higher than does the identically administered free CAI-1 and are diffusive across in vivo delivery barriers such as intestinal mucus. This work highlights the promise of combining quorum-sensing strategies with drug delivery approaches for the development of next-generation medicines.

KW - CAI-1

KW - Nanoparticle

KW - Vibrio cholerae

KW - autoinducer

KW - drug delivery

KW - quorum sensing

UR - http://www.scopus.com/inward/record.url?scp=84926649407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926649407&partnerID=8YFLogxK

U2 - 10.1021/acs.nanolett.5b00151

DO - 10.1021/acs.nanolett.5b00151

M3 - Article

C2 - 25651002

AN - SCOPUS:84926649407

SN - 1530-6984

VL - 15

SP - 2235

EP - 2241

JO - Nano Letters

JF - Nano Letters

IS - 4

ER -

Modulating Vibrio cholerae Quorum-Sensing-Controlled Communication Using Autoinducer-Loaded Nanoparticles

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this