Modelling dynamics of the type I Interferon response to in vitro viral infection

Tom J. Howat, Cristina Barreca, Peter O'Hare, Julia R. Gog, Bryan T. Grenfell

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Innate immunity is crucial in the early stages of resistance to novel viral infection. The family of cytokines known as the interferons (IFNs) forms an essential component of this system: they are responsible for signalling that an infection is underway and for promoting an antiviral response in susceptible cells. We construct a spatial stochastic model, parameterized by experimental data and informed by analytic approximation, to capture the dynamics of virus-IFN interaction during in vitro infection of Madin-Darby bovine kidney cell monolayers by Herpes simplex virus 1. The dose dependence of infection progression, subsequent monolayer destruction and IFN-β production are investigated. Implications for in vivo infections, in particular the priming of susceptible cells by IFN-β during infection, are considered.

Original languageEnglish (US)
Pages (from-to)699-709
Number of pages11
JournalJournal of the Royal Society Interface
Volume3
Issue number10
DOIs
StatePublished - Oct 22 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering

Keywords

  • Cytokines
  • Dose dependence
  • Innate immunity
  • Interferon
  • Stochastic model
  • Viral infection

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