Abstract
The Goldman-Albus treatment of the action-potential dynamics is combined with a phenomenological description of molecular hyperpolarizabilities into a closed-form model of the action-potential-sensitive second-harmonic response of myelinated nerve fibers with nodes of Ranvier. This response is shown to be sensitive to nerve demyelination, thus enabling an optical diagnosis of various demyelinating diseases, including multiple sclerosis. The model is applied to examine the nonlinear-optical response of a three-neuron reverberating circuit-the basic element of short-term memory.
Original language | English (US) |
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Article number | 094702 |
Journal | Journal of Applied Physics |
Volume | 110 |
Issue number | 9 |
DOIs | |
State | Published - Nov 1 2011 |
All Science Journal Classification (ASJC) codes
- General Physics and Astronomy