Modeling the action-potential-sensitive nonlinear-optical response of myelinated nerve fibers and short-term memory

M. N. Shneider, A. A. Voronin, A. M. Zheltikov

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The Goldman-Albus treatment of the action-potential dynamics is combined with a phenomenological description of molecular hyperpolarizabilities into a closed-form model of the action-potential-sensitive second-harmonic response of myelinated nerve fibers with nodes of Ranvier. This response is shown to be sensitive to nerve demyelination, thus enabling an optical diagnosis of various demyelinating diseases, including multiple sclerosis. The model is applied to examine the nonlinear-optical response of a three-neuron reverberating circuit-the basic element of short-term memory.

Original languageEnglish (US)
Article number094702
JournalJournal of Applied Physics
Volume110
Issue number9
DOIs
StatePublished - Nov 1 2011

All Science Journal Classification (ASJC) codes

  • General Physics and Astronomy

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