Modeling Syndromic Congenital Heart Defects in Zebrafish

Meagan G. Grant, Victoria L. Patterson, Daniel T. Grimes, Rebecca D. Burdine

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Scopus citations

Abstract

Cardiac development is a dynamic process regulated by spatial and temporal cues that are integrated to effect molecular, cellular, and tissue-level events that form the adult heart. Disruption of these highly orchestrated events can be devastating for cardiac form and function. Aberrations in heart development result in congenital heart defects (CHDs), which affect 1 in 100 infants in the United States each year. Zebrafish have proven informative as a model organism to understand both heart development and the mechanisms associated with CHDs due to the similarities in heart morphogenesis among vertebrates, as well as their genetic tractability and amenability to live imaging. In this review, we discuss the mechanisms of zebrafish heart development and the utility of zebrafish for understanding syndromic CHDs, those cardiac abnormalities that occur in the context of multisystem disorders. We conclude with avenues of zebrafish research that will potentially inform future therapeutic approaches for the treatment of CHDs.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Developmental Biology
PublisherAcademic Press Inc.
Pages1-40
Number of pages40
DOIs
StatePublished - Jan 1 2017

Publication series

NameCurrent Topics in Developmental Biology
Volume124
ISSN (Print)0070-2153

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

Keywords

  • Cardiac asymmetry
  • Cardiac neural crest
  • Congenital heart defects
  • Endocardium
  • Myocardium
  • Secondary heart field
  • Valvulogenesis
  • Zebrafish

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    Grant, M. G., Patterson, V. L., Grimes, D. T., & Burdine, R. D. (2017). Modeling Syndromic Congenital Heart Defects in Zebrafish. In Current Topics in Developmental Biology (pp. 1-40). (Current Topics in Developmental Biology; Vol. 124). Academic Press Inc.. https://doi.org/10.1016/bs.ctdb.2016.11.010