Modeling hepatitis C virus infection using human induced pluripotent stem cells

Robert E. Schwartz, Kartik Trehan, Linda Andrus, Timothy P. Sheahan, Alexander Ploss, Stephen A. Duncan, Charles M. Rice, Sangeeta N. Bhatia

Research output: Contribution to journalArticle

157 Scopus citations

Abstract

Human pathogens impact patient health through a complex interplay with the host, but models to study the role of host genetics in this process are limited. Human induced pluripotent stem cells (iPSCs) offer the ability to produce host-specific differentiated cells and thus have the potential to transform the study of infectious disease; however, no iPSC models of infectious disease have been described. Here we report that hepatocyte-like cells derived from iPSCs support the entire life cycle of hepatitis C virus, including inflammatory responses to infection, enabling studies of how host genetics impact viral pathogenesis.

Original languageEnglish (US)
Pages (from-to)2544-2548
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume109
Issue number7
DOIs
StatePublished - Feb 14 2012

All Science Journal Classification (ASJC) codes

  • General

Keywords

  • Hepatotrophic infection
  • Host variation in disease
  • Infectious disease model
  • Personalized medicine
  • Viral hepatitis

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