Modeling hepatitis C virus infection using human induced pluripotent stem cells

Robert E. Schwartz; Kartik Trehan; Linda Andrus; Timothy P. Sheahan; Alexander Ploss; Stephen A. Duncan; Charles M. Rice; Sangeeta N. Bhatia

doi:10.1073/pnas.1121400109

Modeling hepatitis C virus infection using human induced pluripotent stem cells

Robert E. Schwartz, Kartik Trehan, Linda Andrus, Timothy P. Sheahan, Alexander Ploss, Stephen A. Duncan, Charles M. Rice, Sangeeta N. Bhatia

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196 Scopus citations

Abstract

Human pathogens impact patient health through a complex interplay with the host, but models to study the role of host genetics in this process are limited. Human induced pluripotent stem cells (iPSCs) offer the ability to produce host-specific differentiated cells and thus have the potential to transform the study of infectious disease; however, no iPSC models of infectious disease have been described. Here we report that hepatocyte-like cells derived from iPSCs support the entire life cycle of hepatitis C virus, including inflammatory responses to infection, enabling studies of how host genetics impact viral pathogenesis.

Original language	English (US)
Pages (from-to)	2544-2548
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	109
Issue number	7
DOIs	https://doi.org/10.1073/pnas.1121400109
State	Published - Feb 14 2012

All Science Journal Classification (ASJC) codes

General

Keywords

Hepatotrophic infection
Host variation in disease
Infectious disease model
Personalized medicine
Viral hepatitis

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10.1073/pnas.1121400109

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abstract = "Human pathogens impact patient health through a complex interplay with the host, but models to study the role of host genetics in this process are limited. Human induced pluripotent stem cells (iPSCs) offer the ability to produce host-specific differentiated cells and thus have the potential to transform the study of infectious disease; however, no iPSC models of infectious disease have been described. Here we report that hepatocyte-like cells derived from iPSCs support the entire life cycle of hepatitis C virus, including inflammatory responses to infection, enabling studies of how host genetics impact viral pathogenesis.",

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AU - Trehan, Kartik

AU - Andrus, Linda

AU - Sheahan, Timothy P.

AU - Ploss, Alexander

AU - Duncan, Stephen A.

AU - Rice, Charles M.

AU - Bhatia, Sangeeta N.

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Modeling hepatitis C virus infection using human induced pluripotent stem cells

Abstract

All Science Journal Classification (ASJC) codes

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