Modeling dynamic reciprocity: Engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation

Celeste M. Nelson, Mina J. Bissell

Research output: Contribution to journalReview article

246 Scopus citations

Abstract

In order to understand why cancer develops as well as predict the outcome of pharmacological treatments, we need to model the structure and function of organs in culture so that our experimental manipulations occur under physiological contexts. This review traces the history of the development of a prototypic example, the three-dimensional (3D) model of the mammary gland acinus. We briefly describe the considerable information available on both normal mammary gland function and breast cancer generated by the current model and present future challenges that will require an increase in its complexity. We propose the need for engineered tissues that faithfully recapitulate their native structures to allow a greater understanding of tissue function, dysfunction, and potential therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)342-352
Number of pages11
JournalSeminars in Cancer Biology
Volume15
Issue number5 SPEC. ISS.
DOIs
StatePublished - Oct 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cancer Research

Keywords

  • Basement membrane
  • Mammary gland
  • Microenvironment
  • Morphogenesis
  • Therapy
  • Tissue structure

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