@article{3b343ced7d7f4fd3b30c6d7b35f1d7ce,
title = "Modeling cancer{\textquoteright}s ecological and evolutionary dynamics",
abstract = "In this didactic paper, we present a theoretical modeling framework, called the G-function, that integrates both the ecology and evolution of cancer to understand oncogenesis. The G-function has been used in evolutionary ecology, but has not been widely applied to problems in cancer. Here, we build the G-function framework from fundamental Darwinian principles and discuss how cancer can be seen through the lens of ecology, evolution, and game theory. We begin with a simple model of cancer growth and add on components of cancer cell competition and drug resistance. To aid in exploration of eco-evolutionary modeling with this approach, we also present a user-friendly software tool. By the end of this paper, we hope that readers will be able to construct basic G function models and grasp the usefulness of the framework to understand the games cancer plays in a biologically mechanistic fashion.",
keywords = "Cancer evolution, Eco-evolutionary dynamics, Evolutionary game theory, Mathematical modeling, Resistance",
author = "Anuraag Bukkuri and Pienta, {Kenneth J.} and Ian Hockett and Austin, {Robert H.} and Hammarlund, {Emma U.} and Amend, {Sarah R.} and Brown, {Joel S.}",
note = "Funding Information: Open access funding provided by Lund University. AB acknowledges support by the Stiftelsen L{\"a}ngmanska kulturfonden (BA22-0753), the Royal Swedish Academy of Sciences Stiftelsen GS Magnusons fond (MG2022-0019), the Crafoord foundation (20220633), and the National Science Foundation Graduate Research Fellowship Program under Grant No. 1746051. KJP is supported by NCI Grants U54CA143803, CA163124, CA093900, and CA143055, and the Prostate Cancer Foundation. JSB acknowledges funding from NIH/NCI, U54CA193489,“Cancer as a complex adaptive system”, NIH/NCI U54 Supplement, “The tumor-host evolutionary arms race”, NIH/NCI, 1R01CA258089, “Eco-evolutionary drivers of clonal dynamics during UV-induced skin carcinogenesis”. SRA is supported by the US Department of Defense CDMRP/PCRP (W81XWH-20-10353), the Patrick C. Walsh Prostate Cancer Research Fund and the Prostate Cancer Foundation. EUH received funding from the ParadOX-ERC Starting Grant (No. 96948), the Crafoord foundation (20220633), and from the Swedish Research Council (Grant 2019-05254). Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
month = apr,
doi = "10.1007/s12032-023-01968-0",
language = "English (US)",
volume = "40",
journal = "Medical Oncology",
issn = "1357-0560",
publisher = "Humana Press",
number = "4",
}